Journal article
Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis
A Catalan, S Tognin, MJ Kempton, D Stahl, G Salazar De Pablo, B Nelson, C Pantelis, A Riecher-Rössler, R Bressan, N Barrantes-Vidal, MO Krebs, M Nordentoft, S Ruhrmann, G Sachs, BPF Rutten, J Van Os, L De Haan, M Van Der Gaag, LR Valmaggia, P McGuire
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2022
Abstract
Background Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR..
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Awarded by National Institute for Health and Care Research
Funding Acknowledgements
We would like to thank all participants who took part in the study. This work was supported by the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-20010-241909; [Project EU-GEI] from the European Community ' s Seventh Framework Programme. Additional support was provided by a Medical Research Council Fellowship to M Kempton (grant MR/J008915/1). N Barrantes-Vidal received additional support from the Ministerio de Ciencia, Innovacion e Universidades (PSI2017-87512-C2-1-R) and the Generalitat de Catalunya (2017SGR1612 and ICREA Academia Award). The study received financial support by French Health Ministry (PHRC, AOM-07-118, 'Influence of cannabis psychopathological outcome in At-risk mental state' (ICAAR study)) et de la Fondation pour la Recherche Medicale (fellowship OG). Sainte-Anne Hospital promoted the study. D Stahl was part-funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London Maudsley Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. C Pantelis was supported by an Australian National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825).